B12 therapeutic use in stroke patients
Authorship
N.M.D.
Bachelor of Nursing (2ª ed) [S]
N.M.D.
Bachelor of Nursing (2ª ed) [S]
Defense date
07.22.2025 10:00
07.22.2025 10:00
Summary
Introduction: Vitamin B12 (VB12) is a water-soluble micronutrient of animal origin essential for several biological processes in which it acts as a cofactor, participating in neurotransmitter synthesis, myelin regeneration, tissue repair, and the reduction of endoplasmic reticulum stress. Stroke is a sudden alteration in neurological function caused by an interruption of cerebral blood flow, which generates cellular damage through a neurotoxic cascade culminating in necrosis or apoptosis. Recent studies show that VB12 could be a limiting factor in cellular plasticity, suggesting that its use could promote regenerative processes. Objectives: To determine the relationship between blood VB12 levels and stroke progression, and to consider creating an intervention plan on the use of VB12 by nursing staff in the management of patients who have suffered a stroke. Methods: A systematic review was conducted using the methodology proposed by the PRISMA declaration in various databases. Several search strategies were used, combining MeSH and DeCS terms and relevant Boolean operators. A series of inclusion/exclusion criteria were also applied to select the included articles. Results: Twelve articles were selected for the systematic review. The reviewed studies suggest that B12 plays an essential role in the pathophysiology and recovery from stroke. Its deficiency is associated with an increased risk of stroke and a worse prognosis. Conclusions: Prophylactic B12 supplementation could have therapeutic potential by improving post-stroke brain plasticity. Nursing-led nutritional intervention, consisting of monitoring blood B12 levels and, if necessary, supplementing B12, could be a simple and cost-effective strategy to enhance functional recovery after the injury.
Introduction: Vitamin B12 (VB12) is a water-soluble micronutrient of animal origin essential for several biological processes in which it acts as a cofactor, participating in neurotransmitter synthesis, myelin regeneration, tissue repair, and the reduction of endoplasmic reticulum stress. Stroke is a sudden alteration in neurological function caused by an interruption of cerebral blood flow, which generates cellular damage through a neurotoxic cascade culminating in necrosis or apoptosis. Recent studies show that VB12 could be a limiting factor in cellular plasticity, suggesting that its use could promote regenerative processes. Objectives: To determine the relationship between blood VB12 levels and stroke progression, and to consider creating an intervention plan on the use of VB12 by nursing staff in the management of patients who have suffered a stroke. Methods: A systematic review was conducted using the methodology proposed by the PRISMA declaration in various databases. Several search strategies were used, combining MeSH and DeCS terms and relevant Boolean operators. A series of inclusion/exclusion criteria were also applied to select the included articles. Results: Twelve articles were selected for the systematic review. The reviewed studies suggest that B12 plays an essential role in the pathophysiology and recovery from stroke. Its deficiency is associated with an increased risk of stroke and a worse prognosis. Conclusions: Prophylactic B12 supplementation could have therapeutic potential by improving post-stroke brain plasticity. Nursing-led nutritional intervention, consisting of monitoring blood B12 levels and, if necessary, supplementing B12, could be a simple and cost-effective strategy to enhance functional recovery after the injury.
Direction
VIEITES PRADO, ALBA (Tutorships)
VIEITES PRADO, ALBA (Tutorships)
Court
TABERNERO DUQUE, MARIA JESÚS (Chairman)
SANCHEZ IGLESIAS, SOFIA (Secretary)
ORDOÑEZ MAYAN, LUCIA (Member)
TABERNERO DUQUE, MARIA JESÚS (Chairman)
SANCHEZ IGLESIAS, SOFIA (Secretary)
ORDOÑEZ MAYAN, LUCIA (Member)