ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Student's work ECTS: 51 Hours of tutorials: 3 Expository Class: 9 Interactive Classroom: 12 Total: 75
Use languages Spanish, Galician, English
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Organic Chemistry
Areas: Organic Chemistry
Center Faculty of Chemistry
Call:
Teaching: Sin docencia (Extinguida)
Enrolment: No Matriculable
• Use the terminology of chemical reactivity, and the appropriate description of stereoselective reactions.
• Ability to handle and communicate, both in writing and orally, the basic concepts of dynamic stereochemistry in Organic Chemistry.
• Become familiar with the three-dimensional representation of molecules, adequately assessing the conformations accessible to them.
• Ability to visualize molecular structures by using models generated by quantum mechanical calculations.
• Understand the relationship between the three-dimensional structure of organic compounds and their reactivity.
• Understand the structural properties and reactivity of the pro-sterogenic centers in the processes in which stereogenic elements are generated.
• Explain in a rational way the result of a chemical reaction in relation to the stereochemistry of the process.
• Know the main types of reactions to create stereogenic centers, understanding their mechanisms.
• Understand the stereoelectronic effects that operate on chemical reactivity.
• Assess the importance of the analysis of transition structures of chemical reactions, and visualize the same obtained by quantum mechanical calculations.
• Understand how the chirality of enantiopure natural compounds can be transmitted to other non-racemic chiral products through chemical transformations.
• Understand how to quantify the relative proportions of diastereoisomers and enantiomers using chemical and physical methods.
• Predict the result of a chemical reaction in which new stereocenters are generated.
• Solve synthetic sequences to obtain non-racemic chiral molecules.
• Acquire and use bibliographic information related to the synthetic processes in which stereocenters are generated.
Unit 1. Stereochemistry in chemical reactions. Conformational control of stereoselectivity.
Unit 2. Additions to trigonal centers C = C.
Unit 3. Additions to trigonal centers C = X.
Unit 4. Conjugate additions to C = C-C = X systems.
Unit 5. Additions to trigonal centers to systems C = C-X.
Unit 6. Reactions between trigonal centers.
Basic (reference manual).
"Asymmetric Synthesis of Natural Products" 2nd ed. Koskinen, A. M. P .; Wiley, New York: 2012.
"Basic Principles of Asymmetric Synthesis" Mulzer, J .; In Comprehensive Asymmetric Catalysis, Jacobsen, E. N .; Pfaltz, A .; Yamamoto, Y. Springer, Heidelberg: 1999; Vol I, chapter 3, pp. 33-100.
Complementary.
"Stereoselective Synthesis". Atkinson, R. S. John Wiley & Sons: Chichester, UK, 1995.
"Asymmetric Synthesis", Procter, G. Oxford University Press, Oxford: 1996.
"Asymmetric Synthetic Methodology", Ager, D. J .; East, M. B. CRC Press, Boca Raton, FL, 1996.
"Enantioselective Chemical Synthesis. Methods, Logic and Practice". Corey, E. J .; Kürti, L. Direct Book Publishing: LLC, 2010.
Basic and general competences
CG2 - Identify information from the scientific literature using the appropriate channels and integrate said information to raise and contextualize a research topic.
CG5 - Use scientific terminology in English to argue experimental results in the context of the chemical profession
CB6 - Possess and understand knowledge that provides a basis or opportunity to be original in the development and / or application of ideas, often in a research context
CB7 - That students know how to apply the knowledge acquired and their ability to solve problems in new or unfamiliar environments within broader (or multidisciplinary) contexts related to their area of study
CB9 - That students know how to communicate their conclusions and the knowledge and ultimate reasons that support them to specialized and non-specialized audiences in a clear and unambiguous way.
CB10 - That students possess the learning skills that allow them to continue studying in a way that will be largely self-directed or autonomous.
SPECIFIC
CE1 - Define concepts, principles, theories and specialized facts of the different areas of Chemistry.
CE2 - Propose alternatives for solving complex chemical problems of the different chemical specialties.
CE4 - Innovate in chemical synthesis and analysis methods related to the different areas of Chemistry.
CE8 - Analyze and use the data obtained autonomously in complex laboratory experiments, relating them to the appropriate chemical, physical or biological techniques, and including the use of primary bibliographic sources.
TRANSVERSAL
CT1 - Prepare, write and publicly defend scientific and technical reports.
CT3 - Work autonomously and efficiently in the daily practice of research or professional activity.
CT4 - Appreciate the value of quality and continuous improvement, acting with rigor, responsibility and professional ethics.
MD1. Lectures to large groups ("L" in the time tables): They will take place in 12 sessions in a group where the theoretical concepts of the course will be presented with relevant examples. The teacher will be helped mainly by Power Point presentations. The students will have access to the copies of the presentations through the virtual teaching platforms, which will allow them to study the course contents prior to the lectures, favoring explanations and the follow-up of the course. Attendance at these classes is compulsory.
MD3. Interactive classes with small groups (Seminars, "S" in the time tables): Four sessions of theoretical / practical class will be held in small groups in which the students will present the work proposed by the teaching staff, which will be followed by the discussion. Students will have access to the proposed exercises and research articles in advance through the virtual teaching platforms. Attendance at these classes is compulsory.
MD3o. Interactive graphic visualization classes (Seminars, “SO” in the time tables): 3 sessions in small groups in which transition structures are visualized for the most important reactions in the course. Attendance at these classes is compulsory.
MD5. Blackboard tutorials in a very small group ("T" in the time tables): There will be two hours of tutorials programmed by the teacher and coordinated by the Center. Activities are proposed such as supervising directed work, clarifying doubts about theory or practices, problems, exercises, readings or other proposed tasks; as well as the presentation, exhibition, debate or comment of individual works or carried out in small groups. Attendance at these classes is compulsory.
The evaluation of this subject will be done through continuous evaluation and the completion of a final exam, access to the exam being conditioned to participation in at least 80% of the compulsory attendance-based teaching activities (seminars and tutorials).
The continuous assessment (L1) will have a weight of 25-45% in the grade of the subject and will consist of two components: small group interactive classes (seminars) and very small group interactive classes (tutorials). The seminars and tutorials will include the following elements: problem solving and practical cases (10-15%), completion of written assignments and reports (5-10%), oral presentation [(practical cases, problems), 5-10%] and oral questions during the course (5-10%).
The final exam (N2) will deal with all the contents of the subject.
The student's grade will be obtained as a result of applying the following formula:
Final mark = maximum (0.4 x N1 + 0.6 x N2)
N1 being the numerical mark corresponding to the continuous assessment (0-10 scale) and N2 the numerical mark of the final exam (0-10 scale).
EVALUATION CRITERIA / WEIGHTING / EVALUATED COMPETENCES /
Final exam / 55-75% / CB6, CB7, CB9, CB10, CT1, CE4, CE1
Troubleshooting and practical cases / 10-15% / CT3, CE4, CE2, CE1, CT3
Oral presentations / 5-10% / CG5, CB9, CB7, CT1, CE4, CE2, CE1
Attendance and participation / 5-10% / CE1, CE2
Assessment of learning objectives and competences /
Training Activity / Hours / Presence
Theoretical face-to-face classes / 12/100%
Seminars / 7/100%
Scheduled tutorials / 2/100%
Test preparation and directed assignments / 18/0%
Student's personal study / 36/0%
• Recommendations for the study of the subject
• It is very important to participate in the lectures.
• Intensive study of the subject is essential since it will be taught in two weeks.
• Once you have finished reading a topic in the reference manual, it is helpful to summarize the important points.
• Problem solving is key to learning this subject.
• It is essential to handle the mechanical models and visualize the structures obtained by quantum mechanical calculations that have been selected for this course.
Francisco Javier Sardina Lopez
Coordinador/a- Department
- Organic Chemistry
- Area
- Organic Chemistry
- Phone
- 881815715
- javier.sardina [at] usc.es
- Category
- Professor: University Professor
| Friday | |||
|---|---|---|---|
| 13:00-14:00 | Grupo /CLE_01 | Spanish | Classroom 2.12 |
| 01.20.2025 16:00-20:00 | Grupo /CLE_01 | Inorganic Chemistry Classroom (1st floor) |