ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 102 Hours of tutorials: 6 Expository Class: 18 Interactive Classroom: 24 Total: 150
Use languages Spanish, Galician, English
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Pharmacology, Pharmacy and Pharmaceutical Technology
Areas: Pharmacology
Center Faculty of Medicine and Dentistry
Call: Second Semester
Teaching: With teaching
Enrolment: Enrollable
Provide students with theoretical-practical training for the validation of pharmacological targets, as well as for the design and execution of preliminary drug screening cascades.
First block: introductory (3c)
1. Preclinical R&D in the process of drug discovery and development.
2. Basic concepts of pharmacology. General mechanisms of action of drugs, specific and nonspecific drugs.
3. Concept of therapeutic targets and antidotes. Experimental validation and clinical validation in the process of drug discovery, beginning tests, efficacy and concept.
4. Pharmacological receptors as drug action targets. Drug-receptor interactions, dose-response curves, affinity and efficacy and their quantification.
Second block: specialized (3c)
1. Identification and validation of targets in the preliminary discovery of drugs. Applied proteomics.
2. Design and execution of preliminary drug discovery cascades: from hits to leads and candidates.
3. Rationalization and design of low (LTS) and high performance (HTS) drug screening campaigns.
4. Methodologies in high and low performance screening: binding, biochemical, fluorescent, cell-based assays, SiRNA, etc.
5. Practical execution of low (LTS) and high (HTS) performance screening campaigns.
The practical classes will be held in the first block in the laboratories of the CIMUS and in the platform of pharmacological evaluation of chemical compounds (USEF) of the University of Santiago de Compostela.
- Kennedy SP and Bormann BJ. Effective partnering of academic and physician scientists with the pharmaceutical drug development industry. Exp Biol Med 2006; 231:1690-4.
- Wunberg T, Hendrix M, Hillisch A, Lobell M, Meier H, Schmeck C, Wild H and Hinzen B. Improving the hit-to-lead process: data-driven assessment of drug-like and lead-like screening hits. Drug Discov Today 2006; 11:175-80.
- Bleicher KH, Bohm HJ, Muller K, Alnine A. A guide to drug discovery: Hit and lead generation: beyond high-throughput screening. Nat Rev Drug Discov 2003; 2:369-78.
- Pereira DA and Williams JA. Origin and evolution of high throughput screening. Br J Pharmacol 2007; 152:53-61.
- Mayr LM and Fuerst P. The Future of High-Throughput Screening. J Biomol Screen 2008; 13:443-48.
- Inglese J, Jonson RL, Simeonov A, Xia M, Zheng W, Austin CP and Auld DS. High-Throughput screening assays for the identification of chemical probes. Nat Chem Biol 2007; 3:466-79.
- Inglese J, Shamu CE and Guy RK. Reporting data from high-throughput screening of small-molecule libraries. Nat Chem Biol 2007; 3:438-41.
- Zhang J, Cheng TDY and Oldenburg KR. A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999; 4:67-73.
- Learning vocabulary in preliminary pharmacology.
- Ability to apply general principles to real situations.
- Ability to work in pharmacological screening.
- Development of a multidisciplinary vision with consultations with experts in the topics of interest of each attendee
The course will be taught as a participatory seminar. Teachers will present the basic concepts in the classes of the theoretical part; students are expected to attend class prepared to discuss these concepts after reading the recommended materials.
The constitution of the groups will be oriented to favor the development of integration skills in multidisciplinary teams of translational research, for which the teachers will favor the participation of students with different basic training in each group.
Students will carry out an individual tutored work-report applying the training received in the course to their own areas of work / interest.
In short, the course will have the following structure:
First block:
- Theoretical classes and seminars focused on the discussion of concepts.
- Job preparation with personalized tutoring
Second block:
- Theoretical classes and seminars focused on the application of the concepts
- Knowledge application to the early drug discovery practices
- Job preparation with personalized tutoring
Both the classes - seminars and the practical demonstrations will be carried out in person according to the established calendar.
- Exam (30% of the final grade). The required work that will have to deliver and present the students in which the knowledge received during the course will be applied will be valued. The presentation of the work will be in person.
- Personal work (50% of the final grade). Represents the application of learning to the specific situation of the work environment / knowledge of the attendees. Personalized tutorials will be conducted
- Continuous assessment (20% of the final grade). The student's attitude will be taken into account throughout the course.
6 ECTS credits, calculating 25 hours per credit (face-to-face and non-face-to-face). Thus, a total of 150 hours are distributed as follows:
1. First introductory block: 3 ECTS credits, 75 hours distributed as follows:
- Classes and seminars: 20 presential hours and 30 hours of personal work of the student (total: 50 hours).
- Other activities:
- Personalized tutorships: 7 presential hours and 12 hours of student work (total 19 hours)
- Searches on the web or library to complete the theory: 6 hours of student work
2. Second block: 3 ECTS credits, 75 hours distributed as follows:
- Classes and seminars: 16 presential hours and 16 hours of personal work of the student (total: 32 hours).
- Practical applications: 20 presential hours plus 4 hours spent by each student in preparing work (total: 24 hours).
- Other activities:
- Personalized tutorships: 4 presential hours and 2 hours of student work (total 6 hours)
- Searches in the network or library to complete the theory: 4 presential hours and 4 hours of student work (total 8 hours)
- Exam: 1 hour
An adequate level of English in reading comprehension and oral communication is essential.
Knowledge or prior reading of a Pharmacology / Pharmacodynamics manual will be helpful
Maria De Los Angeles Castro Perez
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815457
- marian.castro [at] usc.es
- Category
- Professor: University Lecturer
Jose Manuel Brea Floriani
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- pepo.brea [at] usc.es
- Category
- Professor: University Lecturer
Angel Garcia Alonso
- Department
- Pharmacology, Pharmacy and Pharmaceutical Technology
- Area
- Pharmacology
- Phone
- 881815429
- angel.garcia [at] usc.es
- Category
- Professor: University Lecturer
| Tuesday | |||
|---|---|---|---|
| 16:00-20:00 | Grupo /CLE_01 | Galician, Spanish | R.N.S.-Classroom 10 |