ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 102 Hours of tutorials: 6 Expository Class: 18 Interactive Classroom: 24 Total: 150
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Physiology
Areas: Physiology
Center Faculty of Medicine and Dentistry
Call: Second Semester
Teaching: With teaching
Enrolment: Enrollable
In this course, students will become familiar with the study of obesity and its associated complications, as well as relevant bodies involved in the regulation of energy homeostasis.
The approach to the concepts shown will be from the experimental point of view, in order that students develop critical skills with experiments related to the study of obesity to be found throughout his career, and is also able hypotheses and design experiments using the techniques of this science to answer important scientific questions.
1. Concept of balance / energy homeostasis.
Two. Basic methodology in investigating the control of body weight and energy homeostasis. Study models eating pattern, eating behavior and body composition. Measurements of basal energy expenditure and locomotor activity. Models forced physical exercise. Approaches to the study of lipid and carbohydrate metabolism.
Three. Regulation of food intake.
a. Signs of initiation and termination of food intake: neural and humoral factors involved in the short-term regulation.
b. White adipose tissue as energy reserve system and endocrine organ. Other peripheral signals generated depending on the status and distribution of energy deposits in the body. Paper digestive tract, pancreas, liver and muscle tissue. Signaling depending on circulating levels of energy substrates: glucose and free fatty acids.
c. Central mechanisms regulating intake. Orexigenic and anorexigenic hypothalamic circuits. Involvement of other areas of the CNS: the brain stem. Mechanisms nonhomeostatic reward systems.
April. Components of energy expenditure.
a. Basal metabolic rate. Endocrine regulation of the metabolism of carbohydrates and lipids.
b. Energy expenditure associated with exercise.
c. Adaptive thermogenesis. Brown adipose tissue and skeletal muscle: uncoupling protein UCP.
d. Relevance of the sympathetic nervous system in the regulation of energy expenditure: resting metabolic rate, thermogenic effect of food, energy cost of physical activity and adaptive thermogenesis.
May. Energy Homeostasis: immune system and stress.
June. Mechanisms of adaptation in conditions of energy imbalance:
a. Fasting and exercise: regulation of hepatic and muscle metabolism.
b. Energy homeostasis and reproduction: pregnancy and breastfeeding.
c. Pathological conditions:
i. Obesity and metabolic syndrome.
ii. Diabetes.
iii. Disorders of eating behavior.
iv. Malnutrition.
July. Clinical intervention strategies in the treatment of obesity:
a. Dietary approach.
b. Exercise pattern.
c. Pharmacological approach.
d. Surgical approach.
August. Nutrition:
a. Requirements and human nutritional recommendations.
b. Nutrition during pregnancy and lactation.
c. Nutrition for growth and development.
d. Nutritional Requirements and recommendations in the elderly.
e. Nutrition and physical activity.
The gut and energy balance: visceral allies in the obesity wars.
Badman MK, Flier JS.
Science. 2005 Mar 25;307(5717):1909-14.
Obesity wars: molecular progress confronts an expanding epidemic.
Flier JS.
Cell. 2004 Jan 23;116(2):337-50.
Central nervous system control of food intake.
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG.
Nature. 2000 Apr 6;404(6778):661-71.
The need to feed: homeostatic and hedonic control of eating.
Saper CB, Chou TC, Elmquist JK.
Neuron. 2002 Oct 10;36(2):199-211.
Interacting appetite-regulating pathways in the hypothalamic regulation of body weight.
Kalra SP, Dube MG, Pu S, Xu B, Horvath TL, Kalra PS.
Endocr Rev. 1999 Feb;20(1):68-100.
a.-General:
• able to organize and plan, under supervision, the development of a research project.
• Being able to work together to achieve common goals from different perspectives.
• Be able to discuss the most relevant literature in the area, and have the ability to carry out critical reasoning about hypotheses, experimental approaches or previous experiments, both in the study area and in wider contexts.
• Be able to disseminate the results and conclusions obtained in the experiments
Handle with ease the various bibliographic databases relevant to biomedical research.
• Possessing learning skills necessary for continuing education in the field of biomedicine in a self-directed or autonomous.
b.-Specific:
• Understanding the cellular and molecular mechanisms essential for the maintenance of energy balance in the body, whose alteration explains the development of various human diseases.
• Approaching the most important concepts of the regulation of energy metabolism from the experimental standpoint.
• Be able to design, develop and use appropriate methodology for experimentally addressing a problem posed in the field of study of energy homeostasis and nutrition.
• Understand the concepts and processes of integration and coordination hormone metabolism. Relate hormonal variations that occur in different physiological and pathological situations with their effects.
• Ability to use correct terminology in the area of metabolism and endocrinology.
• Be able to integrate the latest advances in the study of body weight regulation and energy homeostasis.
• Be able to apply this knowledge in the field of human nutrition.
• Depth knowledge of the physiological basis of human nutrition and nutritional needs of the different stages of life in physiological and pathological conditions.
• Understand the methodology for the assessment of dietary habits and have the ability to design nutritional intervention strategies, both in physiological and pathological situations.
-Theory
- Seminar discussion of research articles, experimental protocols.
Attendance and participation
During the course, each student will present some work, be prepared individually
Attending classes, both theory and seminars.
Consultation recommended bibliography.
Use the tutorials for any questions you may have.
Carlos Dieguez Gonzalez
- Department
- Physiology
- Area
- Physiology
- Phone
- 881812258
- carlos.dieguez [at] usc.es
- Category
- Professor: University Professor
Sulay A. Tovar Carro
Coordinador/a- Department
- Physiology
- Area
- Physiology
- Phone
- 881815456
- sulay.tovar [at] usc.es
- Category
- Professor: Temporary PhD professor
Miguel Antonio Lopez Perez
- Department
- Physiology
- Area
- Physiology
- Phone
- 881815420
- m.lopez [at] usc.es
- Category
- Professor: University Professor
Ismael Gonzalez Garcia
- Department
- Physiology
- Area
- Physiology
- ismael.gonzalez [at] usc.es
- Category
- Researcher: Ramón y Cajal
| Tuesday | |||
|---|---|---|---|
| 09:30-10:30 | Grupo /CLE_01 | Spanish | R.N.S.-Classroom 10 |
| Thursday | |||
| 11:30-13:30 | Grupo /CLE_01 | Spanish | R.N.S.-Classroom 10 |