Design and characterization of personalized tablets for cats by 3D printing using semi solid extrusion
Authorship
L.C.Q.
Bio-manufacturing Master's Degree
L.C.Q.
Bio-manufacturing Master's Degree
Defense date
07.15.2025 09:00
07.15.2025 09:00
Summary
An oral personalized formulation of gabapentin for cats was developed using semi solid extrusion 3D printing, aiming to improve palatability and ease of dosing. Three anhydrous bases were evaluated, with Klear Gummy standing out of its compatibility with the drug and good printability. Minimu and maximum doses in the 40 to 100 mg range were tested, with only the 100 mg dose meeting pharmacopoeial standards and showing progressive and stable drug release. Although the lower dose was not suitable, the technique appears to be a promising option for personalized veterinary medicine, requiring further optimization to ensure efficacy and reproducibility
An oral personalized formulation of gabapentin for cats was developed using semi solid extrusion 3D printing, aiming to improve palatability and ease of dosing. Three anhydrous bases were evaluated, with Klear Gummy standing out of its compatibility with the drug and good printability. Minimu and maximum doses in the 40 to 100 mg range were tested, with only the 100 mg dose meeting pharmacopoeial standards and showing progressive and stable drug release. Although the lower dose was not suitable, the technique appears to be a promising option for personalized veterinary medicine, requiring further optimization to ensure efficacy and reproducibility
Direction
GARCIA GONZALEZ, CARLOS ALBERTO (Tutorships)
Bendicho Hernández, José Carlos (Co-tutorships)
GARCIA GONZALEZ, CARLOS ALBERTO (Tutorships)
Bendicho Hernández, José Carlos (Co-tutorships)
Court
DIAZ RODRIGUEZ, PATRICIA (Chairman)
serra rodriguez, julia asuncion (Secretary)
Díaz Prado, Silvia M. (Member)
DIAZ RODRIGUEZ, PATRICIA (Chairman)
serra rodriguez, julia asuncion (Secretary)
Díaz Prado, Silvia M. (Member)
Role of angiotensin-converting enzyme 2 (ACE2) in the regulation of adult neurogenesis
Authorship
M.C.S.
Bio-manufacturing Master's Degree
M.C.S.
Bio-manufacturing Master's Degree
Defense date
07.15.2025 09:00
07.15.2025 09:00
Summary
The ventricular-subventricular zone (V-SVZ) is the largest neurogenic niche in the adult mammalian brain. Therefore, its regenerative capacity is potentially useful as a treatment for different neurodegenerative diseases. Previous studies by the research group in which this work was carried out demonstrated the expression of components of the renin angiotensin system (RAS) in this region, as well as their involvement in neurogenic processes. However, the potential role of the angiotensin converting enzyme 2 (ACE2), key in the RAS balance, in the neurogenesis of this niche remains unknown. Our results show that ACE2 is expressed in neural stem cells and progenitor cells of the adult mouse V-SVZ, and that its activation, mediated by Mas receptors, promotes their activation. These results suggest that ACE2 could be a novel therapeutic target to promote regenerative processes in the adult brain.
The ventricular-subventricular zone (V-SVZ) is the largest neurogenic niche in the adult mammalian brain. Therefore, its regenerative capacity is potentially useful as a treatment for different neurodegenerative diseases. Previous studies by the research group in which this work was carried out demonstrated the expression of components of the renin angiotensin system (RAS) in this region, as well as their involvement in neurogenic processes. However, the potential role of the angiotensin converting enzyme 2 (ACE2), key in the RAS balance, in the neurogenesis of this niche remains unknown. Our results show that ACE2 is expressed in neural stem cells and progenitor cells of the adult mouse V-SVZ, and that its activation, mediated by Mas receptors, promotes their activation. These results suggest that ACE2 could be a novel therapeutic target to promote regenerative processes in the adult brain.
Direction
RODRIGUEZ PALLARES, JANNETTE (Tutorships)
LABANDEIRA GARCIA, JOSE LUIS (Co-tutorships)
RODRIGUEZ PALLARES, JANNETTE (Tutorships)
LABANDEIRA GARCIA, JOSE LUIS (Co-tutorships)
Court
DIAZ RODRIGUEZ, PATRICIA (Chairman)
Simón Vázquez, Rosana (Secretary)
Díaz Prado, Silvia M. (Member)
DIAZ RODRIGUEZ, PATRICIA (Chairman)
Simón Vázquez, Rosana (Secretary)
Díaz Prado, Silvia M. (Member)
Development of a Microfluidic System with implementation of functionalized Magnetic Nanoparticles for the selective isolation of biological Biomarkers.
Authorship
P.H.S.
Bio-manufacturing Master's Degree
P.H.S.
Bio-manufacturing Master's Degree
Defense date
07.15.2025 09:00
07.15.2025 09:00
Summary
Extracellular vesicles (EVs), particularly exosomes, are emerging as key elements in the diagnosis and prognosis of various diseases due to their role in intercellular communication and their presence in different biological fluids. However, their small size and low concentration make their isolation technically challenging. In this context, microfluidic devices offer an innovative solution. These systems allow the handling of very small sample volumes with precise fluid control, while also enabling the integration of multiple processes on a single chip. Their versatility and customization potential make them particularly suitable for advanced biomedical applications. This work focuses on the design and development of a microfluidic device capable of effectively capturing extracellular vesicles or other biomolecules using magnetic nanoparticles functionalized with specific antibodies. The proposed system will include a mixing stage followed by a capture stage using a magnetic field. The goal is to achieve a precise, cost-effective, and reproducible system for particle separation in complex and low-concentration samples.
Extracellular vesicles (EVs), particularly exosomes, are emerging as key elements in the diagnosis and prognosis of various diseases due to their role in intercellular communication and their presence in different biological fluids. However, their small size and low concentration make their isolation technically challenging. In this context, microfluidic devices offer an innovative solution. These systems allow the handling of very small sample volumes with precise fluid control, while also enabling the integration of multiple processes on a single chip. Their versatility and customization potential make them particularly suitable for advanced biomedical applications. This work focuses on the design and development of a microfluidic device capable of effectively capturing extracellular vesicles or other biomolecules using magnetic nanoparticles functionalized with specific antibodies. The proposed system will include a mixing stage followed by a capture stage using a magnetic field. The goal is to achieve a precise, cost-effective, and reproducible system for particle separation in complex and low-concentration samples.
Direction
GARCIA GONZALEZ, CARLOS ALBERTO (Tutorships)
Ferreiro Vila, Elías (Co-tutorships)
Silva Candal, Andrés Alexander da (Co-tutorships)
GARCIA GONZALEZ, CARLOS ALBERTO (Tutorships)
Ferreiro Vila, Elías (Co-tutorships)
Silva Candal, Andrés Alexander da (Co-tutorships)
Court
DIAZ RODRIGUEZ, PATRICIA (Chairman)
Chiusi , Stefano (Secretary)
Díaz Prado, Silvia M. (Member)
DIAZ RODRIGUEZ, PATRICIA (Chairman)
Chiusi , Stefano (Secretary)
Díaz Prado, Silvia M. (Member)