ECTS credits ECTS credits: 6
ECTS Hours Rules/Memories Student's work ECTS: 99 Hours of tutorials: 3 Expository Class: 24 Interactive Classroom: 24 Total: 150
Use languages Spanish, Galician, English
Type: Ordinary Degree Subject RD 1393/2007 - 822/2021
Departments: Organic Chemistry
Areas: Organic Chemistry
Center Faculty of Chemistry
Call: Second Semester
Teaching: With teaching
Enrolment: Enrollable
Acquire fundamental knowledge about the structural characteristics, physical properties, reactivity and synthetic methodologies of the main types of biomolecules.
THEORETICAL PART.
Unit 1. Carbohydrates.
1.1. Nomenclature and carbohydrate structure. 1.2. Conformations and cyclic forms of sugars. 1.3. Anomers. Glucose mutarotation. 1.4. Reactivity of sugars as polyfunctional compounds. Oxidation to carboxylic acids. Oxidative cleavage. 1.5. Reduction of monosaccharides to alditols. 1.6. Reaction with nitrogen derivatives. 1.7. Formation of esters and ethers: glycosides. 1.8. Synthesis and gradual degradation of sugars. 1.9. Disaccharides. 1.10. Polysaccharides.
Unit 2. Amino acids, peptides and proteins.
2.1. Introduction. Heterocycles of biological relevance. 2.2. Structure and properties of amino acids. 2.3. Synthesis of amino acids. 2.4. The peptide bond. 2.5. Peptides and proteins. 2.6. Determination of primary structure. Polypeptides sequencing. 2.7. Polypeptide synthesis. 2.8. Solid-phase Merrifield synthesis.
Unit 3. Nucleic Acids.
3.1. Nucleotides, nucleosides and nucleic acids. Structure, nomenclature and function. 3.2. DNA sequencing. 3.3. Chemical synthesis of DNA.
Unit 4. Lipids.
4.1. Lipids. Structure and properties.
Unit 5. Secondary metabolites. Main biosynthetic pathways.
5.1. Introduction. 5.2. Polyketides. Biosynthetic pathway. 5.3. Phenylpropanoids. Shikimic acid pathway. 5.4. Terpenoids. Terpenes, steroids, carotenoids. Terpenoids biosynthesis. 5.5. Nitrogenated natural compounds.
EXPERIMENTAL PART.
Six laboratory practices in six sessions of four hours each.
1. Introduction.
2. Synthesis of a dipeptide: Methyl N-acetyl-L-prolyl-L-phenylalanate (3 sessions).
3. Structural analysis of peptides (1.5 sessions).
4. Glucose acetylation (0.5 sessions).
5. Isolation of a natural product from its source (1 session).
Basic bibliography.
1. Organic Chemistry. Structure and Function, 8th edition. K. Peter C. Vollhardt, Neil E. Schore. W. H. Freeman and Company, New York: 2018. (Main textbook).
2. Organic Chemistry. 12th Edition, Solomon and Fryhle. Ed. Wiley, 2015.
3. Natural Products: the Secondary Metabolites. James R. Hanson. RCS (Tutorial Chemistry Texts), Cambridge (UK), 2003.
Complementary bibliography.
Laboratory bibliography.
4. Técnicas Experimentales en Síntesis Orgánica. Mª Á. Martínez Grau, A. G. Csákÿ. Ed. Síntesis: Madrid, 2001-2008.
5. Website of Servicio de Prevención de Riscos de la USC: (http://www.usc.es/estaticos/servizos/sprl/normalumlab.pdf)
6. Experimental Organic Chemistry. L.M. Harwood, C. J. Moody. Ed. Blackwell Scientific Publications.
Advanced bibliography.
7. Chemical Aspects of Biosynthesis. J. Mann. Oxford Chemistry Primers, Ed. Oxford University Press: New York, 1994.
BASIC AND GENERAL
GC1 - That graduates possess and understand the concepts, methods and most important results of the various branches of chemistry, with a historical perspective of their development.
GC2 - That they are able to gather and interpret data, information and relevant results, draw conclusions and issue reasoned reports in scientific and technological subjects or from other areas requiring the use of chemical knowledge.
GC3 - That they can apply both theoretical and practical knowledge acquired as the ability of analysis and abstraction in the definition and approach to problems and search for solutions of both academic and professional contexts.
GC4 - To have the ability to communicate, both written and orally, knowledge, procedures, results and ideas in Chemistry both at a skilled and unskilled audience.
GC5 - That they are able to study and learn independently, with organization of time and resources, new knowledge and techniques in any scientific or technological discipline.
BC1 - That the students had shown to have and to understand knowledges in a field of study that starts from the basis of general secondary education, and it is in a level that, although supported by advanced textbooks, it also includes some aspects involving knowledge of the forefront of their field of study.
5.5.1.5.2 TRANSVERSE COMPETENCES
TC1 - Acquire capacity for analysis and synthesis.
TC2 - Develop capacity for organization and planning.
TC3 - To acquire knowledge of a foreign language.
CT4 - Be able to solve problems.
TC5 - Be able to make decisions.
5.5.1.5.3 SPECIFIC COMPETENCES
SC25 - Being able to relate chemistry with other disciplines.
SC12 - Knowing the structure and reactivity of the main classes of biomolecules and the chemistry of the main biological processes.
SC18 - Be able to perform laboratory procedures involved in standards analytical and synthetic work in conjunction with organic and inorganic systems.
SC23 - Recognize and value chemical processes in everyday life.
SC24 - Being able to understand the qualitative and quantitative aspects of chemical problems.
I) Classroom teaching activities: Consisting of lectures, interactive small group classes (seminars and tutorials) and interactive classes of laboratory (practices):
A) Lectures in large group: Lesson taught by the teacher which may have different formats (theory, problems and / or general examples, general guidelines of the matter ...).
B) Interactive classes in small group (seminars): theoretical/practical class to propose and solve applications of theory, problems, exercises ... The student should participate actively in these classes in different ways: handling solved exercises to the teacher; solving exercises in the classroom, etc. Attendance at these classes is mandatory.
C) Tutorials in small group: theoretical/practical classes to performs different activities such as the supervision of assignments, clarification of doubts about the theory or practice, problems, exercises, readings or other tasks. Attendance at these classes is mandatory. Tutorials will be essentially face-to-face, although they may be partially carried out virtually.
D) Laboratory practical classes: We include here classes that take place in a laboratory and that can be complemented in the general services rooms or in the computer room. In them the student acquires the skills of a chemistry lab and consolidate the knowledge acquired in the theory classes. For these practices, the student will have a laboratory manual, which will include general considerations for working in the
laboratory and a summary of the practices to be done, which will consist of a brief presentation of the foundations, the methodology to be followed and the indication of the calculations to be performed and results to be presented. Students must attend every practice session having previously read carefully the contents of this manual and resolved some preliminary questions that the teacher will qualify and take into account for the practices note. After an explanation of the teacher, the students will perform individually the calculations and experiments necessary to achieve the objectives of the practice, and write in a laboratory notebook the procedure, calculations and outcome of the experiment, presenting the same day or the next session the results, which will be evaluated.
The laboratory notebook in which the procedures followed and the results achieved are written as indicated in the laboratory manual, will be evaluated in situ by the professor.
Attendance at these classes is mandatory. Absences must be justified properly, accepting reasons of examination and health, as well as cases falling within the existing university regulations. Unrealized practices must be recovered in accordance with the teacher and within the scheduled time for the subject.
II) Non-contact teaching activities: personal work dedicated to the preparation of the matter.
III) Virtual Classroom: There is a virtual classroom where students find all the information and materials relating to the subject: teaching guide, presentations, problem sets, laboratory manual, notices, etc. Through the virtual classroom students will deliver the exercises in seminars and tutorials ...
The assessment of this subject will be done through continuous assessment and the completion of a final exam.
Continuous assessment (N1) will weigh 30% in the grade for the course and will consist of three components: small group interactive classes (seminars, 55%), interactive classes in very small groups (tutorials, 5%) and practical and laboratory (40%). Seminars and tutorials will include exercises and personal work in the class or delivered to the teacher.
For the evaluation of laboratory practices items to evaluate are: pre-test and understanding of the experiment, organization and neatness in the laboratory, practice execution and laboratory notebook.
The final exam will cover all the contents of the course and will include issues of laboratory practices.
The student's score, which shall not be less than the final exam, will be obtained as a result of applying the following formula:
Score = maximum Note (0.3 x N1 + 0.7 x N2, N2)
N1 is the score corresponding to the continuous assessment (scale 0-10) and N2 is the final exam (0-10 scale) numerical grade.
In any case, to pass the subject it will be an essential requirement to have a pass grade in the laboratory/computer practices and the exam grade cannot be lower than 4 out of 10.
Attendance at seminars and tutorial classes is mandatory. It will be necessary to attend at least 80% of these classes for the continuous evaluation to be assessed.
Repeater students who have passed laboratory/computer practices in a previous edition, they retain the grade obtained in this item for up to two academic years.
In the case of fraudulent exercises or tests, the provisions of the "Regulations for the assessment of students' academic performance and the revision of qualifications" shall apply.
Each of the four blocks of evaluation (seminars, tutorials, laboratory work and final examination) wiil evaluate the following competences:
Seminars: BC1; GC 1, 2, 4; TC2, 4; SC12, 23
Tutorials: BC1; GC 1, 4; TC2; SC12, 23
Laboratory work: BC1; GC 1, 3, 5; TC2, 4, 5; SC12, 18, 23, 24
Exam: BC1; GC 1, 3, 5; TC1, 2, 4; SC12, 24
The number of ECTS credits of this subject is 6 (4 credits theoretical/practical + 2 laboratory), corresponding to 150 total hours of student work:
WORK IN THE CLASSROOM (hours)
Lectures in large group 19
Small group interactive classes (seminars) 9
Very small group tutorials 2
Laboratory Practices 30
Total working hours in the classroom or in the laboratory 60
PERSONAL WORK
Total hours personal work 90
• It is highly recommended to attend lectures.
• It is important to the study of matter on a daily basis.
• After the reading of a topic in the reference manual, it is useful to summarize the important points, basic concepts and reactions to remember.
• The resolution of exercises is essential for learning this subject. For exercises involving concepts of stereochemistry it is advisable to use molecular models. For reactivity exercises may be helpful to follow these steps: (1) Identify the functional groups and the type of compound. (2) Identify the changes that may experience these groups and the reaction conditions. (3) Consider the stereochemistry of the starting materials and selectivity of the reaction.
• It is essential the preparation of the practices before entering the laboratory. First, you should review the important theoretical concepts in each experiment and then you need to read carefully the procedure, trying to understand the objectives and the development of the proposed experiment. Any doubts that may arise must be discussed with the teacher.
Manuel Maria Paz Castañal
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- Phone
- 881814218
- manuel.paz [at] usc.es
- Category
- Professor: University Lecturer
Maria Rita Paleo Pillado
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- Phone
- 881814453
- rita.paleo [at] usc.es
- Category
- Professor: University Lecturer
Mercedes Torneiro Abuin
Coordinador/a- Department
- Organic Chemistry
- Area
- Organic Chemistry
- Phone
- 881814224
- mercedes.torneiro [at] usc.es
- Category
- Professor: University Lecturer
Adrián Martínez Castrillón
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- amartinez.castrillon [at] usc.es
- Category
- Ministry Pre-doctoral Contract
Maria Tomas Gamasa
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- Phone
- 881815760
- maria.tomas [at] usc.es
- Category
- Researcher: Ramón y Cajal
Jesus Fernando Salgado Barca
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- jesusfernando.salgado.barca [at] usc.es
- Category
- Xunta Pre-doctoral Contract
Álvaro Maza Barón
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- alvaro.maza.baron [at] usc.es
- Category
- Xunta Pre-doctoral Contract
Adrian Rivas Saborido
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- adrianrivas.saborido [at] usc.es
- Category
- Ministry Pre-doctoral Contract
Manuel Nappi
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- manuel.nappi [at] usc.es
- Category
- Researcher: Ramón y Cajal
Kaddy Saho
- Department
- Organic Chemistry
- Area
- Organic Chemistry
- ka.saho [at] usc.es
- Category
- Ministry Pre-doctoral Contract
| Tuesday | |||
|---|---|---|---|
| 12:00-13:00 | Grupo /CLE_03 | English | Classroom 3.44 |
| 12:00-13:00 | Grupo /CLE_02 | Spanish | Inorganic Chemistry Classroom (1st floor) |
| 13:00-14:00 | Grupo /CLE_01 | Spanish | Organic Chemistry Classroom (1st floor) |
| Wednesday | |||
| 09:00-10:00 | Grupo /CLE_01 | Spanish | Organic Chemistry Classroom (1st floor) |
| Thursday | |||
| 11:00-12:00 | Grupo /CLE_03 | English | Classroom 3.44 |
| 11:00-12:00 | Grupo /CLE_02 | Spanish | Inorganic Chemistry Classroom (1st floor) |
| 05.19.2025 16:00-20:00 | Grupo /CLE_01 | Biology Classroom (3rd floor) |
| 05.19.2025 16:00-20:00 | Grupo /CLE_01 | Mathematics Classroom (3rd floor) |
| 07.04.2025 10:00-14:00 | Grupo /CLE_01 | Physical Chemistry Classroom (ground floor) |
| 07.04.2025 10:00-14:00 | Grupo /CLE_01 | Technical Chemistry Classroom (ground floor) |