ECTS credits ECTS credits: 3
ECTS Hours Rules/Memories Student's work ECTS: 51 Hours of tutorials: 3 Expository Class: 9 Interactive Classroom: 12 Total: 75
Use languages Spanish, Galician
Type: Ordinary subject Master’s Degree RD 1393/2007 - 822/2021
Departments: Functional Biology
Areas: Cellular Biology
Center Faculty of Optics and Optometry
Call: First Semester
Teaching: With teaching
Enrolment: Enrollable | 1st year (Yes)
- Students will describe the components of the immune system, their interactions and their function.
- Students will analyze the immune response against pathogens.
- Students will understand the changes that occur in immune diseases, transplants and tumors.
- Students will understand and compare the immune response in the different compartments and components of the eye, and its regulation during inflammation and infection.
- Students will identify the most appropriate techniques to evaluate the immune response.
Theoretical class program (9 hours).
LECTURE 1.- Cells and organs of the immune system.
LECTURE 2.- Innate immunity. Cells and molecules that mediate innate immunity. NK activity. Soluble mediators. Complement system and its regulation. Inflammatory response.
LECTURE 3.- Adaptive immunity. Cells and molecules that mediate adaptive immunity. Types, development, survival of lymphocytes and antigenic recognition.
LECTURE 4.- Antigenic processing and recognition. The Major Histocompatibility Complex (MHC).
LECTURE 5.- Effector mechanisms of cellular and humoral immunity. Immunity mediated by T cells. B cells and generation of antibodies.
LECTURE 6.- Mucosal immunity. Response to infection and regulation.
LECTURE 7.- Immune-based diseases. Autoimmunity. Hypersensitivity. Transplants. Antitumor immunity.
LECTURE 8.- Manipulation of the immune response.
LECTURE 9.- Overview of the ocular immune response. Mucosal immunity. T cell-mediated immunity. Innate immunity in the eye. Tears, ocular surface and immune response. Role of the complement system in the ocular immune response. Ocular immune privilege. The inflammatory response in the eye. Mechanisms of ocular hypersensitivity. Ocular autoimmunity. Diagnostic and research techniques in ocular immunology.
Seminars (14 hours).
Preparation of the subject in each seminar by the students. The lecturers will explain the basic concepts and resolve any doubts that may arise to the students in the preparation of the contents of the seminars. The students will have to answer questions about these contents.
Tutorship (1 hour).
In the tutorship, the course programming will be explained, recommendations for organizing and studying the subject will be given and any doubts that students may have in relation to it will be solved.
Recommended book for the preparation of theoretical classes
Inmunología básica. (2024). Abbas , A.K.; Lichtman, A.H.; Pillai, S. 7ª edición. Editorial Elsevier. ISBN: 9788413826578. Dispoñible en liña no buscador Iacobus da biblioteca: https://www.usc.gal/gl/servizos/area/biblioteca-universitaria
Complementary bibliography
Abbas, A. K. et al. (2022). Inmunología celular y molecular. 10ª edición. Barcelona: Elsevier Saunders.
Dartt, D.A. et al. (2011). Immunology, Inflammation and Diseases of the Eye. San Diego, CA: Academic Press.
Delves P. J. et al. (2014). Roitt. Inmunología. Fundamentos. 12ª ed. Buenos Aires : Editorial Médica Panamericana.
Rojas Espinosa, O. (2017). Inmunología: (de memoria). 4ª ed. Buenos Aires; Madrid : Editorial Médica Panamericana.
Reviews on ocular immunology
Caspi, R.R. (2010). A look at autoimmunity and inflammation in the eye. J Clin Invest. 120: 3073-3083.
Caspi, R.R. (2013). In this issue: Immunology of the eye-inside and out. Int Rev Immunol. 32: 1-3.
de Paiva C.S., Leger A.J., Caspi, R.R. (2022). Mucosal immunology of the ocular surface. Mucosal Immunol. 15(6): 1143-1157. Doi: 10.1038/s41385-022-00551-6.
Forrester, J.V., Xu, H. (2012). Good news-bad news: the Yin and Yang of immune privilege in the eye. Front Immunol. 27: 338.
Knopa, R., Knopb, N. (2007). Anatomy and immunology of the ocular ourface. En "Immune Response and the Eye". Eds. Niederkorn JY, Kaplan HJ. Chem Immunol Allergy. Basel, Karger. pp. 36–49.
La Rosa, M., Lionetti, E., Reibaldi, M., Russo, A., Longo, A., Leonardi, S., Tomarchio, S., Avitabile, T., Reibaldi, A. (2013). Allergic conjunctivitis: a comprehensive review of the literature. Ital J Pediatr. 39: 18.
Mochizuki, M. (2010). Regional immunity of the eye. Acta Ophthalmol. 88: 292–299.
Mochizuki, M., Sugita, S., Kamoi, K. (2013). Immunological homeostasis of the eye. Prog Ret Eye Res. 33: 10e27.
Niederkorn, J.Y. (2011). Cornea: Window to Ocular Immunology. Curr Immunol Rev. 7: 328-335.
Niedźwiedzka-Rystwej, P., Deptuła, J., Deptuła, J. (2012). Immunology of the eye – selected data. Centr Eur J Immunol 37: 71-74.
O’Sullivan, N., Montgomery, P.C. (2015). Ocular Mucosal Immunity. En "Mucosal Immunity", 4ª ed. Editores: Jiri Mestecky Warren Strober Michael Russell Hilde Cheroutre Bart N. Lambrecht Brian Kelsall. Londress: Academic Press. pp. 1873-1897.
Perez, V.L., Saeed, A.M., Tan, Y., Urbieta, M., Cruz-Guilloty, F. (2013). The eye: A window to the soul of the immune system. J Autoimmun. 45: 7-14.
Stein-Streilein, J. (2008). Immune regulation and the eye. Trends Immunol. 29: 548-54.
Taylor, A.W. (2016). Ocular immune privilege and transplantation. Front Immunol. 7:37. eCollection 2016.
Taylor, A.W., (2018). Negative regulators that mediate ocular immune privilege. J Leukoc Biol. Feb 12. doi: 10.1002/JLB.3MIR0817-337R.
Taylor AW, Hsu S, Ng TF. (2021). The Role of Retinal Pigment Epithelial Cells in Regulation of Macrophages/Microglial Cells in Retinal Immunobiology. Front Immunol. 12: 724601.
Zarei-Ghanavati, M., Liu, C. (2017). Aspects of Corneal Transplant Immunology. J Ophthalmic Vis Res. 12: 249-250.
Basic skills
CG3 - Acquire knowledge and skills necessary for incorporation into specialized professional practice and research in the field of Optometry.
CB6 - Possess and understand knowledge that provides a basis or opportunity to be original in the development and/or application of ideas, often in a research context.
CB7 - That students know how to apply the acquired knowledge and their ability to solve problems in new or little-known environments within broader (or multidisciplinary) concepts related to their area of study.
CB8 - That students are able to integrate knowledge and face the complexity of formulating judgments based on information that, being incomplete or limited, includes reflections on the social and ethical responsibilities linked to the application of their knowledge and judgments.
CB9 - That students know how to communicate their conclusions and the ultimate knowledge and reasons that support them to specialized and non-specialized audiences in a clear and unambiguous way.
CB 10 - That students possess the learning skills that allow them to continue studying in a way that will be largely self-directed or autonomous.
Transversal skills
CT1 - Participate in debates and discussions, direct and coordinate them and be able to summarize them and extract from them the most relevant conclusions accepted by the majority.
CT2 - Use the different techniques of oral and written presentations, presentations, panels, etc., to communicate their knowledge, proposals and positions.
CT3 - Develop critical, self-critical and decision-making capacity.
CT4 - Ability to manage Information and Communication Technologies (ICT).
CT5 - Ability to reflect from various perspectives of knowledge.
Specific skills
CE3 - Apply knowledge from the field of Immunology to any study in Optometry, designing experiments and using the most advanced techniques and tools.
CE7 - Acquire knowledge and skills from different perspectives of vision science knowledge.
- Theoretical classes (no presential). The Virtual USC will include detailed information about the theoretical concepts that are necessary to know to pass the subject. At the beginning of the course, a work plan will be sent to the students indicating the content to be prepared for each seminar and the bibliography used.
- Mandatory classroom seminars. The lecturers will explain the basic concepts and resolve any doubts that may arise to the students in the contents preparation the seminars. Students must answer questions about these contents. Students must answer questions about contents of basic immunology, and contents of ocular immunology will be explained.
- Tutorship. The course programming will be explained, recommendations will be given to organize and study the subject and students' doubts in relation to it will be resolved.
- Students must pass an exam of contents explained in lectures that represent 65% of the final grade. Passing grade is 5 out of 10.
Assessed skills: CG3, CB6, CB7, CB8, CB9, CB10, CT2, CT3, CT4, CT5, CE3, C37.
- Mandatory seminars will represent 35% of the final grade. In the seminars in which contents of basic immunology are discussed, students will answer questions about those contents.
Assessed skills: CG3, CB6, CB7, CB8, CB95, CB10, CT1, CT2, CT5, CE3, C37.
- Once the exam is passed, the qualification obtained in the seminar will be added.
- Repeating students will not have to take the seminars if they have already taken them in previous years (the grade obtained is kept). Although the students will repeat the seminars if they consider it, they may improve (or lower) the grade they already had.
- Theory: 30 hours of personal work.
- Seminars: 14 hours classwork and 28 hours of personal work.
- Tutorship: 1 hour.
- Taking exams: 2 hours.
- Total hours of classwork: 17 hours.
- Total personal work hours: 58 hours.
- Total time dedicated to the subject: 75 hours.
- Study of the contents provided by the lecturers and study of the recommended book. It is necessary to know the theory on general immunology, corresponding to each seminar, before carrying it out, since the students will have to answer questions about these contents.
- Weekly study and review of the subject.
- Preparation of the seminars proposed prior to classwork.
- Clarification of possible doubts with the lecturers (via email or through a tutorship).
- Review for the final exam.
This subject will have a virtual classroom on the Moodle platform available to students.
In cases of fraudulent completion of exercises or tests, the "Regulations for the evaluation of the academic performance of students and the review of grades" will be applied.
Manuel Noia Guldrís
Coordinador/a- Department
- Functional Biology
- Area
- Cellular Biology
- Phone
- 881816948
- manuel.guldris [at] usc.gal
- Category
- Professor: University Lecturer
Jesus Lamas Fernandez
- Department
- Functional Biology
- Area
- Cellular Biology
- Phone
- 881816951
- jesus.lamas [at] usc.es
- Category
- Professor: University Professor
| Thursday | |||
|---|---|---|---|
| 16:00-18:00 | Grupo /CLIS_01 | Galician | Classroom 5 |
| 12.16.2024 16:00-18:00 | Grupo /CLE_01 | Classroom 3 |
| 06.09.2025 16:00-18:00 | Grupo /CLE_01 | Classroom 3 |